ParkinsonCanadaV1, Main, Exploration, bibRecord, 000413

Choice of dopaminergic therapy among early, mild Parkinson disease subjects in North America.

Identifieur interne : 000413 ( Main/Exploration ); précédent : 000412; suivant : 000414

Choice of dopaminergic therapy among early, mild Parkinson disease subjects in North America.

Auteurs : John L. Goudreau [États-Unis] ; Adriana Pérez [États-Unis] ; Michael J. Aminoff [États-Unis] ; James T. Boyd [États-Unis] ; Keith D. Burau [États-Unis] ; Chadwick W. Christine [États-Unis] ; Maureen Leehey [États-Unis] ; John C. Morgan [États-Unis]

Source :

Journal of the neurological sciences [ 1878-5883 ] ; 2016.

RBID : pubmed:27288780

English descriptors

KwdEn :
- Age Factors, Aged, Antiparkinson Agents (therapeutic use), Canada (epidemiology), Choice Behavior, Dopamine Agents (therapeutic use), Educational Status, Female, Humans, Logistic Models, Male, Middle Aged, Monoamine Oxidase Inhibitors (therapeutic use), Multivariate Analysis, Parkinson Disease (drug therapy), Parkinson Disease (epidemiology), Patient Acceptance of Health Care (statistics & numerical data), Time Factors, Treatment Outcome, United States (epidemiology).
MESH :
- chemical , therapeutic use : Antiparkinson Agents, Dopamine Agents, Monoamine Oxidase Inhibitors.
- drug therapy : Parkinson Disease.
- epidemiology : Canada, Parkinson Disease, United States.
- statistics & numerical data : Patient Acceptance of Health Care.
- Age Factors, Aged, Choice Behavior, Educational Status, Female, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Time Factors, Treatment Outcome.

Abstract

The choice of dopaminergic therapy in early Parkinson disease (PD) is an important clinical decision, yet factors influencing this decision have not been extensively studied. We sought to investigate the factors that may be associated with the choice of dopaminergic therapy at the NINDS Exploratory Trials in PD (NET-PD) Long-Term Study-1 (LS1). NET-PD LS1 was a clinical trial of creatine versus placebo in participants with early, mild PD on stable doses of dopaminergic therapy. Baseline data from 1616 out of the 1741 participants were evaluated using univariable and multivariable logistic or generalized logit regression analyses for available factors associated with the choice of dopaminergic therapy. The dopaminergic therapy choice was determined as: (i) therapy that subjects recalled taking 180days before the study; (ii) therapy at baseline; and (iii) the longest duration of therapy reported by participants. Younger age, higher education level, longer length of time since PD diagnosis and use of an adjunctive, non-dopaminergic or monoamine oxidase inhibitor medication were associated with more frequent use of dopamine agonist compared to levodopa or combination therapy.

DOI: 10.1016/j.jns.2016.04.021
PubMed: 27288780

Affiliations:

Le document en format XML

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<term>Choice Behavior</term>
<term>Dopamine Agents (therapeutic use)</term>
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<term>Humans</term>
<term>Logistic Models</term>
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<term>Multivariate Analysis</term>
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<term>Parkinson Disease (epidemiology)</term>
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<term>Monoamine Oxidase Inhibitors</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">The choice of dopaminergic therapy in early Parkinson disease (PD) is an important clinical decision, yet factors influencing this decision have not been extensively studied. We sought to investigate the factors that may be associated with the choice of dopaminergic therapy at the NINDS Exploratory Trials in PD (NET-PD) Long-Term Study-1 (LS1). NET-PD LS1 was a clinical trial of creatine versus placebo in participants with early, mild PD on stable doses of dopaminergic therapy. Baseline data from 1616 out of the 1741 participants were evaluated using univariable and multivariable logistic or generalized logit regression analyses for available factors associated with the choice of dopaminergic therapy. The dopaminergic therapy choice was determined as: (i) therapy that subjects recalled taking 180days before the study; (ii) therapy at baseline; and (iii) the longest duration of therapy reported by participants. Younger age, higher education level, longer length of time since PD diagnosis and use of an adjunctive, non-dopaminergic or monoamine oxidase inhibitor medication were associated with more frequent use of dopamine agonist compared to levodopa or combination therapy.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Choice of dopaminergic therapy among early, mild Parkinson disease subjects in North America.

Choice of dopaminergic therapy among early, mild Parkinson disease subjects in North America.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.